IGF-1 LR3 Peptide (Long R3 IGF-1) is a modified analogue of insulin-like growth factor-1 (IGF-1) designed for research involving growth-factor signaling and the IGF-1 receptor pathway. IGF-1 LR3 contains structural modifications that reduce its interaction with IGF-binding proteins while retaining activity at the IGF-1 receptor.
Research involving IGF-1 LR3 Peptide has focused on IGF-1 receptor signaling, cellular growth, proliferation, differentiation, cell survival, and related intracellular pathways such as PI3K/Akt.
Product Highlights
Modified IGF-1 analogue
Also known as Long R3 IGF-1
83-amino-acid growth-factor protein
Studied in IGF-1 receptor research
Used in cellular growth and signaling research
Investigated in muscle, tissue, and cell-culture research
Potential Research Benefits of IGF-1 LR3
IGF-1 receptor activation
IGF-1 LR3 retains activity at the IGF-1 receptor, allowing researchers to study downstream growth and signaling mechanisms.
Cell growth and proliferation research
IGF-1 receptor signaling is involved in cellular growth and proliferation, making LR3 useful for experimental studies of these processes.
Cell survival research
IGF signaling participates in pathways associated with cell survival and protection from programmed cell death.
Reduced IGF-binding protein interaction
One defining feature of LR3 is its substantially lower affinity for IGF-binding proteins compared with native IGF-1. This makes it useful for studying IGF activity when IGFBP interactions are being investigated.
Muscle and protein-metabolism research
Animal studies have investigated LR3 in relation to muscle protein preservation and whole-body protein metabolism. These findings should not be interpreted as proof of equivalent muscle-building effects in humans.
Growth and tissue-development research
Experimental studies have IGF-1 LR3 Peptide examined IGF-1/LR3 signaling in tissue growth and developmental processes.
PI3K/Akt and related signaling research
IGF-1 receptor activation connects with intracellular pathways including PI3K/Akt and MAPK/ERK, which are important areas of growth-factor research.